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Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency

Qiqi Zhao, Xin Gao, Guangli Yan, Aihua Zhang, Hui Sun, Ying Han, Wenxiu Li, Liang Liu, Xijun Wang

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 335-356 doi: 10.1007/s11684-019-0705-9

Abstract: However, the quality control (QC) standards of SJZD are insufficient.study, we used Chinmedomics to evaluate the SJZD’s efficacy against SQDS to discover the potential quality-markersA total of 58 biomarkers were related to SQDS, and SJZD can adjust a large proportion of marker metabolitesisoglabrolide, and glycyrrhetnic acid as the q-markers of licorice; and 2-atractylenolide as the q-markerAccording to the discovery of the SJZD q-markers, we can establish the quality standard that is related

Keywords： traditional Chinese medicine     Sijunzi decoction     spleen qi deficiency syndrome     Chinmedomics     quality-marker    

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Overview of the quality standard research of traditional Chinese medicine

Huimin Gao, Zhimin Wang, Yujuan Li, Zhongzhi Qian

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 195-202 doi: 10.1007/s11684-011-0134-x

Abstract: However, one of the biggest challenges facing the clinical practice of TCM is the uncontrollable qualityIn this review, the progress of the development and the current status of quality standard as well asnew quality control techniques introduced in (2010 edition), such as liquid chromatography hyphenatedmass spectrometry (LC-MS), fingerprint, quantitative analysis of multi-components by single-marker (QAMS), thin layer chromatography bio-autographic assay (TLC-BAA), and DNA molecular marker technique,

Keywords： traditional Chinese medicine     quality standard     quality control     quantitative analysis of multi-componentsby single-marker    

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Quality Markers of Traditional Chinese Medicine: Concept, Progress, and Perspective Review

Yazhuo Li, Ying Xie, Yufei He, Wenbin Hou, Maoliang Liao, Changxiao Liu

Engineering 2019, Volume 5, Issue 5,   Pages 888-894 doi: 10.1016/j.eng.2019.01.015

Abstract: Current quality control of herbal medicines, however, is in great dispute.Unlike chemical drugs, which have clear and validated quality standards, the content of only one (ormarker that was proposed in previous work is discussed further here.markers and new quality control patterns.The progress that has been made in TCM quality control is also addressed.

Keywords： Traditional Chinese medicine     Quality marker     Quality control    

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Transcriptome resources and genome-wide marker development for Japanese larch (

Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 1,   Pages 77-84 doi: 10.15302/J-FASE-2014010

Abstract: While the differential responses of trees to changes in climatic and environmental conditions have been demonstrated as they age, the underlying mechanisms and age control of tree growth and development are complex and poorly understood particularly at a molecular level. In this paper, we present a transcriptome analysis of , a deciduous conifer that is widely-grown in the northern hemisphere and of significant ecological and economic value. Using high-throughput RNA sequencing, we obtained about 26 million reads from the stems of 1-, 2-, 5-, 10-, 25- and 50-year-old trees. Combining these with the published Roche 454 sequencing reads and the expressed sequence tags (both mainly from embryogenic cell cultures), we assembled 26670549 reads into 146786 transcripts, of which we annotated 79182 to support investigations of the molecular basis of tree aging and adaption, somatic embryogenesis and wood formation. Using these sequences we also identified many single-nucleotide polymorphisms, simple sequence repeats, and insertion and deletion markers to assist breeding and genetic diversity studies of .

Keywords： Larix     transcriptome     age     wood formation     somatic embryogenesis     molecular marker    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 52-60 doi: 10.1007/s11684-016-0433-3

Abstract:  Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target

Keywords： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Novel polymorphic EST-based microsatellite marker isolation and characterization from

Manosh Kumar BISWAS,Peng CHEN,Mohamed Hamdy AMAR,Xiuxin DENG

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 60-65 doi: 10.15302/J-FASE-2015048

Abstract: Novel simple sequence repeat (SSR) markers were developed to evaluate their utility for genetic diversity and breeding studies of and related species. A total of 108 primer pairs were characterized by PCR amplification experiments. Among these, 61 were polymorphic and transferable to other citrus species. The number of alleles per locus ranged from 2 to 6, with an average of 2.37 alleles per locus. The expected heterozygosity and observed heterozygosity ranged from 0 to 0.83 and 0 to 1.00, respectively. These novel polymorphic SSR markers will be useful for citrus cultivar identification and evaluation as well as breeding studies.

Keywords： microsatellite     polymorphism     Poncirus trifoliata    

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Erratum to “Targeted Genotyping of a Whole-Gene Repertoire by an Ultrahigh-Multiplex and Flexible HD-Marker Erratum

Pingping Liu,Jia Lv,Cen Ma,Tianqi Zhang,Xiaowen Huang,Zhihui Yang,Lingling Zhang,Jingjie Hu,Shi Wang,Zhenmin Bao,

Engineering 2022, Volume 18, Issue 11,   Pages 259-259 doi: 10.1016/j.eng.2022.09.002

Keywords： online     THE AUTHORS.Published     repertoire     behalf     Engineering     September     genotyping     Academy     HD-marker approach    

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China-CIMMYT collaboration enhances wheat improvement in China

Zhonghu HE, Xianchun XIA, Yong ZHANG, Yan ZHANG, Yonggui XIAO, Xinmin CHEN, Simin LI, Yuanfeng HAO, Awais RASHEED, Zhiyong XIN, Qiaosheng ZHUANG, Ennian YANG, Zheru FAN, Jun YAN, Ravi SINGH, Hans-Joachim BRAUN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3,   Pages 233-239 doi: 10.15302/J-FASE-2019254

Abstract: A standardized protocol for testing Chinese noodle quality has been established with three selectioncriteria, i.e., gluten quality, starch viscosity and flour color are identified as being responsiblefor noodle quality.establishment of a KASP platform, and seven cultivars have been released through application of molecular marker

Keywords： adult-plant resistance     bread wheat     breeding     gene-specific marker     germplasm exchange     processing quality    

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From total quality management to Quality 4.0: A systematic literature review and future research agenda

Frontiers of Engineering Management 2023, Volume 10, Issue 2,   Pages 191-205 doi: 10.1007/s42524-022-0243-z

Abstract: Quality 4.0 is an emerging concept that has been increasingly appreciated because of the intensificationIt deals with aligning quality management practices with the emergent capabilities of Industry 4.0 toimprove cost, time, and efficiency and increase product quality.concept, Quality 4.0 implementation, quality management in Quality 4.0, and Quality 4.0 model and applicationthe quality curve theory, and highlight future research opportunities.

Keywords： quality management     Quality 4.0     Industry 4.0     literature review     predictive quality    

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as proxies for yield potential and heat stress tolerance in spring wheat: heritability estimates and marker-trait

Caiyun LIU, Francisco PINTO, C. Mariano COSSANI, Sivakumar SUKUMARAN, Matthew P. REYNOLDS

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 3,   Pages 296-308 doi: 10.15302/J-FASE-2019269

Abstract: using 18704 single nucleotide polymorphisms (SNPs) from Illumina iSelect 90K identified 280 and 43 marker-traitHigh heritability estimates and identification of marker-trait associations indicate that SRIs are useful

Keywords： genome-wide association study (GWAS)     heat tolerance     spectral reflectance     spring wheat    

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UNREDUCED MEGAGAMETOPHYTE FORMATION VIA SECOND DIVISION RESTITUTION CONTRIBUTES TO TETRAPLOID PRODUCTION IN INTERPLOIDY CROSSES WITH ‘ORAH’ MANDARIN (CITRUS RETICULATA)

Frontiers of Agricultural Science and Engineering 2021, Volume 8, Issue 2,

Abstract:

Seedless fruits are desirable in the citrus fresh fruit market. Triploid production via diploid × tetraploid interploidy crosses is thought to be the most efficient and widely-used strategy for the breeding of seedless citrus. Although ‘Orah’ mandarin has desirable organoleptic qualities, seeds in the fruits weaken its market competitiveness. To produce new seedless cultivars that are similar to ‘Orah’ mandarin, we performed three 2x × 4x crosses using ‘Orah’ mandarin as the seed parent to regenerate triploid plantlets. A total of 182 triploid and 36 tetraploid plantlets were obtained. By analyzing their genetic origins using nine novel single nucleotide polymorphism (SNP) markers, all of the triploids and tetraploids derived from these three crosses were proven to be hybrids. Also, we demonstrated that 2n megagametophyte formation in ‘Orah’ mandarin result in tetraploid production in these three interploidy crosses. These tetraploid plantlets were genotyped using eight pericentromeric SNP markers and nine centromere distal SNP markers. Based on the genotypes of the 2n megagametophytes, the parental heterozygosity rates in 16 SNP loci and all 2n megagametophytes were less than 50%, indicating that second division restitution was the mechanism underlying 2n megagametophyte formation at both the population and individual levels. These triploid hybrids enrich the germplasm available for seedless breeding. Moreover, the tetraploid hybrids are valuable as parents for ploidy breeding for the production of seedless citrus fruits.

 

Keywords： Citrus / 2n gamete / interploidy hybridization / pericentromeric SNP marker / second division restitution    

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Research and establishment of enterprise quality metadata standard

SONG Han, LI Jie, ZHANG Genbao

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 1,   Pages 106-110 doi: 10.1007/s11465-008-0019-0

Abstract: Enabling quality managers to utilize and manage quality data efficiently under modern quality managementcircumstances is a primary issue for improving enterprise quality management.A concept of quality metadata is proposed in this paper, which can help quality managers gain a deeperunderstanding of various features of quality data and establish a more stable foundation for furtherThe procedure of establishing quality metadata standards is emphasized in the paper, and the content

Keywords： enterprise quality     foundation     description     quality management     primary    

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Foxtail millet: nutritional and eating quality, and prospects for genetic improvement

Lu HE,Bin ZHANG,Xingchun WANG,Hongying LI,Yuanhuai HAN

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 2,   Pages 124-133 doi: 10.15302/J-FASE-2015054

Abstract: more important than ever to develop breeding strategies that facilitate the increasing demand for high qualityHere we review research on foxtail millet quality evaluation, appearance, cooking and eating qualityimportant crop, outline current status of breeding of foxtail millet, and make suggestions to improve grain quality

Keywords： foxtail millet     grain quality     quality evaluation     breeding for quality    

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A review of hydrological/water-quality models

Liangliang GAO,Daoliang LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 267-276 doi: 10.15302/J-FASE-2014041

Abstract: Water quality models are important in predicting the changes in surface water quality for environmentalA range of water quality models are wildly used, but every model has its advantages and limitations forThe aim of this review is to provide a guide to researcher for selecting a suitable water quality modelEight well known water quality models were selected for this review: SWAT, WASP, QUALs, MIKE 11, HSPF

Keywords： water quality models     applications     future trends    

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Evaluation of ICUs and weight of quality control indicators: an exploratory study based on Chinese ICUquality data from 2015 to 2020

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 675-684 doi: 10.1007/s11684-022-0970-x

Abstract: This study aimed to explore key quality control factors that affected the prognosis of intensive careWe found that 15 initially established quality control indicators were good predictors of patient prognosisdifferent weights of the core elements associated with the 15 indicators, we developed an integrated qualityThis evidence-based quality scoring system will help in assessing the key elements of quality managementand establish a foundation for further optimization of the quality control indicator system.

Keywords： critical care medicine     quality control     evaluation     exploratory factor analysis (EFA) model    

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Title Author Date Type Operation

Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency

Qiqi Zhao, Xin Gao, Guangli Yan, Aihua Zhang, Hui Sun, Ying Han, Wenxiu Li, Liang Liu, Xijun Wang

Journal Article

Overview of the quality standard research of traditional Chinese medicine

Huimin Gao, Zhimin Wang, Yujuan Li, Zhongzhi Qian

Journal Article

Quality Markers of Traditional Chinese Medicine: Concept, Progress, and Perspective

Yazhuo Li, Ying Xie, Yufei He, Wenbin Hou, Maoliang Liao, Changxiao Liu

Journal Article

Transcriptome resources and genome-wide marker development for Japanese larch (

Wanfeng LI,Suying HAN,Liwang QI,Shougong ZHANG

Journal Article

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

Zhi Xu,Chunxiang Cao,Haiyan Xia,Shujing Shi,Lingzhi Hong,Xiaowei Wei,Dongying Gu,Jianmin Bian,Zijun Liu,Wenbin Huang,Yixin Zhang,Song He,Nikki Pui-Yue Lee,Jinfei Chen

Journal Article

Novel polymorphic EST-based microsatellite marker isolation and characterization from

Manosh Kumar BISWAS,Peng CHEN,Mohamed Hamdy AMAR,Xiuxin DENG

Journal Article

Erratum to “Targeted Genotyping of a Whole-Gene Repertoire by an Ultrahigh-Multiplex and Flexible HD-Marker

Pingping Liu,Jia Lv,Cen Ma,Tianqi Zhang,Xiaowen Huang,Zhihui Yang,Lingling Zhang,Jingjie Hu,Shi Wang,Zhenmin Bao,

Journal Article

China-CIMMYT collaboration enhances wheat improvement in China

Zhonghu HE, Xianchun XIA, Yong ZHANG, Yan ZHANG, Yonggui XIAO, Xinmin CHEN, Simin LI, Yuanfeng HAO, Awais RASHEED, Zhiyong XIN, Qiaosheng ZHUANG, Ennian YANG, Zheru FAN, Jun YAN, Ravi SINGH, Hans-Joachim BRAUN

Journal Article

From total quality management to Quality 4.0: A systematic literature review and future research agenda

Journal Article

as proxies for yield potential and heat stress tolerance in spring wheat: heritability estimates and marker-trait

Caiyun LIU, Francisco PINTO, C. Mariano COSSANI, Sivakumar SUKUMARAN, Matthew P. REYNOLDS

Journal Article

UNREDUCED MEGAGAMETOPHYTE FORMATION VIA SECOND DIVISION RESTITUTION CONTRIBUTES TO TETRAPLOID PRODUCTION IN INTERPLOIDY CROSSES WITH ‘ORAH’ MANDARIN (CITRUS RETICULATA)

Journal Article

Research and establishment of enterprise quality metadata standard

SONG Han, LI Jie, ZHANG Genbao

Journal Article

Foxtail millet: nutritional and eating quality, and prospects for genetic improvement

Lu HE,Bin ZHANG,Xingchun WANG,Hongying LI,Yuanhuai HAN

Journal Article

A review of hydrological/water-quality models

Liangliang GAO,Daoliang LI

Journal Article

Evaluation of ICUs and weight of quality control indicators: an exploratory study based on Chinese ICUquality data from 2015 to 2020

Journal Article